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KMID : 1147720150080030134
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Journal of Acupuncture and Meridian Studies
2015 Volume.8 No. 3 p.134 ~ p.141
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Antitumor and Wound Healing Properties of Rubus ellipticus Smith
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George Blassan Plackal
Parimelazhagan Thangaraj
Kumar Yamini T.
Sajeesh Thankarajan
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Abstract
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The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to in vitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher in vitro antioxidant activity, was taken for the evaluation of in vivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of 2 g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13th day and the 19th day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton's lymphoma ascite (DLA) solid tumors (2.56 cm3). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.
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KEYWORD
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antioxidant, antitumor, Rubus ellipticus, wound healing
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